The antihypertensive sodium nitroprusside contains cyanide. Domestic fires, industrial accidents, and sodium nitroprusside are more common possible causes of cyanide poisoning.įabrics, upholstery, and melamine (often used as a coating on shelves and cabinets) can all give off cyanide when burned.Ĭyanide is used in the extraction of gold and silver, and the production of nylon.
The capacity to metabolize cyanide is limited, and just ~0.5mg/kg is enough to be fatal.Ĭyanide toxicity is relatively rare. Oxygen supply remains adequate but cells are unable to utilize the oxygen.Ĭyanide is present in low background levels in the environment and is safely metabolized to thiocyanate by the liver. It causes death within minutes to hours of exposure.Ĭyanide inhibits oxidative phosphorylation in the mitochondria, shutting down aerobic metabolism.
Subscribe on iTunes, Android, or StitcherĬyanide is a rapidly lethal toxin. In this episode I’ll discuss cyanide toxicity.
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